Scientific publications of research projects supported by Hirslanden are available here.

2024

Predicting parameters of airway dynamics generated from inspiratory and expiratory plethysmographic airway loops, differentiating subtypes of chronic obstructive diseases

Kraemer R.; Smith H.J.; Reinstaedtler J.; Gallati S.; Matthys H. 

Assessment of functional diversities in patients with Asthma, COPD, Asthma-COPD overlap, and Cystic Fibrosis (CF)

Kraemer R.; Baty F.; Smith H.J.; Minder S.; Gallati S.; Brutsche M.H.; Matthys H. 

Small airway disease assessed by parameters of small airway dysfunction in patients with asthma, asthma-chronic obstructive pulmonary disease-overlap, and chronic obstructive pulmonary disease

Dynamic parameters of fluid responsiveness in the operating room

Prütz M, Bozkurt A, Löser B, Haas SA, Tschopp D, Rieder P, Trachsel S, Vorderwülbecke G, Menk M, Balzer F, Treskatsch S, Reuter DA, Zitzmann A. Dynamic parameters of fluid responsiveness in the operating room : An analysis of intraoperative ventilation framework conditions. Anaesthesiologie. 2024 Jul;73(7):462-468. doi: 10.1007/s00101-024-01428-y. Epub 2024 Jun 28. PMID: 38942901; PMCID: PMC11222210.

2023

The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus.

Kaidar-Person O et al. The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus. eClinicalMedicine – Part of The Lancet Discovery Science. Volume 61, July 2023.

DOI: https://doi.org/10.1016/j.eclinm.2023.102085

Follow-Up of Celiac Disease in Adults : «When, What, Who, and Where»

Mulder, C.J.J.; Elli, L.; Lebwohl, B.; Makharia, G.K.; Rostami, K.; Rubio-Tapia, A.; Schumann, M.; Tye-Din, J.; Zeitz, J.; Al-Toma, A. (2023): «Follow-Up of Celiac Disease in Adults: When, What, Who, and Where». Nutrients 2023, 15, 2048. 

DOI: 10.3390/nu15092048

The Impact of Age in the Treatment of Non-comorbid Patients with Rectal Cancer

Erdem, S., Warschkow, R., Studer, P. et al. The Impact of Age in the Treatment of Non-comorbid Patients with Rectal Cancer: Survival Outcomes from the National Cancer Database. World J Surg (2023). 

DOI: s00268-023-07008-2

SARS-CoV-2 risk in household contacts of healthcare workers: a prospective cohort study. Antimicrob Resist Infect Control 12, 98

Philipp Kohler, Tamara Dörr, Andrée Friedl, Reto Stocker, Danielle Vuichard, Stefan P. Kuster, Christian R. Kahlert on behalf of the SURPRISE Study Group (2023). 

DOI: s13756-023-01300-5

Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination—A prospective multicentre cohort of health professionals (SURPRISE study). Influenza Other Respi Viruses.

Philipp Kohler 1, Baharak Babouee Flury1,Sabine Güsewell1 | Thomas Egger1 | Onicio Leal2,3 | Angela Brucher4 | Eva Lemmenmeier5 | Dorette Meier Kleeb6 | J. Carsten Möller 7 | Manuela Ortner8 | Philip Rieder9 | Markus Ruetti10 | Hans-Ruedi Schmid11 | Reto Stocker9 | Danielle Vuichard-Gysin 12 | Oliver Speer 13 | Benedikt Wiggli14 | Ulrike Besold15 | Allison McGeer16 | Lorenz Risch 17,18,19 | Andrée Friedl13 | Matthias Schlegel 1 | Pietro Vernazza 1 | Christian R. Kahlert1,20 | Stefan P. Kuster1 | SURPRISE Study Group (2023).

DOI: 10.1111/irv.13167

Post-Acute Sequelae After Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Viral Variant and Vaccination Status: A Multicenter Cross-Sectional Study. Clinical Infectious Diseases, Volume 77, Issue 2

Philipp Kohler 1, Baharak Babouee Flury1,Sabine Güsewell1 | Thomas Egger1 | Onicio Leal2,3 | Angela Brucher4 | Eva Lemmenmeier5 | Dorette Meier Kleeb6 | J. Carsten Möller 7 | Manuela Ortner8 | Philip Rieder9 | Markus Ruetti10 | Hans-Ruedi Schmid11 | Reto Stocker9 | Danielle Vuichard-Gysin 12 | Oliver Speer 13 | Benedikt Wiggli14 | Ulrike Besold15 | Allison McGeer16 | Lorenz Risch 17,18,19 | Andrée Friedl13 | Matthias Schlegel 1 | Pietro Vernazza 1 | Christian R. Kahlert1,20 | Stefan P. Kuster1 | SURPRISE Study Group (2023).

DOI: 10.1093/cid/ciad143

Clinical symptoms of SARS-CoV-2 breakthrough infection during the Delta and Omicron waves in relation to baseline immune status and booster vaccination – a prospective multicentre cohort of health professionals (SURPRISE study) Influenza Other Respir Viruses.

Philipp Kohler MD, Baharak Babouee Flury MD, Sabine Güsewell PhD, Thomas Egger MSc, Onicio Leal PhD, Angela Brucher MD, Eva Lemmenmeier MD, Dorette Meier Kleeb MD, J. Carsten Möller MD, Manuela Ortner, Philip Rieder PhD, Markus Ruetti MD, Hans-Ruedi Schmid PhD, Reto Stocker MD, Danielle Vuichard-Gysin MD, Oliver Speer PhD, Benedikt Wiggli MD, Ulrike Besold MD, Allison McGeer MD, Lorenz Risch MD, Andrée Friedl MD, Matthias Schlegel MD, Pietro Vernazza MD, Christian R. Kahlert* MD, Stefan P. Kuster MD, SURPRISE Study Group (2023).

DOI: 10.1111/irv.13167

2022

Impact of respirator versus surgical masks on SARS-CoV-2 acquisition in healthcare workers: a prospective multicentre cohort.

Haller S, Güsewell S, Egger T, Scanferla G, Thoma R, Leal-Neto OB, Flury D, Brucher A, Lemmenmeier E, Möller JC, Rieder P, Rütti M, Stocker R, Vuichard-Gysin D, Wiggli B, Besold U, Kuster SP, McGeer A, Risch L, Schlegel M, Friedl A, Vernazza P, Kahlert CR, Kohler P. Impact of respirator versus surgical masks on SARS-CoV-2 acquisition in healthcare workers: a prospective multicentre cohort. Antimicrob Resist Infect Control. 2022 Feb 5;11(1):27.

DOI: 10.1186/s13756-022-01070-6

Symptoms compatible with long-COVID in healthcare workers with and without SARS-CoV-2 infection - results of a prospective multicenter cohort.

Strahm C, Seneghini M, Güsewell S, Egger T, Leal O, Brucher A, Lemmenmeier E, Meier Kleeb D, Möller JC, Rieder P, Ruetti M, Rutz R, Schmid HR, Stocker R, Vuichard-Gysin D, Wiggli B, Besold U, Kuster SP, McGeer A, Risch L, Friedl A, Schlegel M, Schmid D, Vernazza P, Kahlert CR, Kohler P. Symptoms compatible with long-COVID in healthcare workers with and without SARS-CoV-2 infection - results of a prospective multicenter cohort. Clin Infect Dis. 2022 Jan 28:ciac054.
DOI: 10.1093/cid/ciac054

Cerebral Amyloid Angiopathy and the Risk of Hematoma Expansion.

Seiffge DJ, Polymeris AA, Law ZK, Krishnan K, Zietz A, Thilemann S, Werring D, Salaman RA, Dineen RA, Engelter ST, Bath PM, Sprigg N, Lyrer P, Peters N. Cerebral Amyloid Angiopathy and the Risk of Hematoma Expansion. Annals of Neurology. 2022 (921-930). Volume 92, No. 6. Published by Wiley Periodicals LLC on behalf of American Neurological Association.

DOI: 10.1002/ana.26481

Recombinant ADAMTS13 for Hereditary Thrombotic Thrombocytopenic Purpura.

Asmis L, Serra A, Krafft A, Licht A, Leisinger E, Henschkowski-Serra J, Ganter MT, Hauptmann S, Tinguely M, Kremer Hovinga JA. Recombinant ADAMTS13 for Hereditary Thrombotic Thrombocytopenic Purpura. The New England Journal of Medicine. N Engl J Med 2022;387:2356-61.

DOI: 10.1056/NEJMoa2211113

Functional Predictors Discriminating Asthma-COPD Overlap (ACO) from Chronic Obstructive Pulmonary Disease (COPD).

Kraemer R, Gardin F, Smith HJ, Baty F, Barandun J, Piecyk A, Minder S, Salomon J, Frey M, Brutsche MH, Matthys H. Functional Predictors Discriminating Asthma-COPD Overlap (ACO) from Chronic Obstructive Pulmonary Disease (COPD). 2022. International Journal of Chronic Obstructive Pulmonary Disease, 17, 2723-2743.

DOI: 10.2147/COPD.S382761

Risk and symptoms of COVID-19 in health professionals according to baseline immune status and booster vaccination during the Delta and Omicron waves in Switzerland—A multicentre cohort study. PLOS Medicine

Baharak Babouee Flury, Sabine Güsewell, Thomas Egger, Onicio Leal, Angela Brucher, Eva Lemmenmeier, Dorette Meier Kleeb, J. Carsten Möller, Philip Rieder, Markus Rütti, Hans-Ruedi Schmid, Reto Stocker, Danielle Vuichard-Gysin [ ... ],on behalf of the SURPRISE Study Group (2022).

DOI: journal.pmed.1004125

Impact of respirator versus surgical masks on SARS-CoV-2 acquisition in healthcare workers: a prospective multicentre cohort. Antimicrobial Resistance & Infection Control volume 11, Article number: 27

Haller S, Güsewell S, Egger T, […], Stocker R, et al. Impact of respirator versus surgical masks on SARS-CoV-2 acquisition in healthcare workers: a prospective multicentre cohort. Antimicrobial Resistance & Infection Control volume 11, Article number: 27 (2022).

DOI: s13756-022-01070-6

2021

Breast conservation and axillary management after primary systemic therapy in patients with early-stage breast cancer: the Lucerne toolbox.

Dubsky P et al. Breast conservation and axillary management after primary systemic therapy in patients with early-stage breast cancer: the Lucerne toolbox. The Lancet Oncology. Volume 22, Issue 1. January 2021; p. e18-e28.

DOI: https://doi.org/10.1016/S1470-2045(20)30580-5

Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19-a prospective multicenter cohort study.

Kohler P, Güsewell S, Seneghini M, Egger T, Leal O, Brucher A, Lemmenmeier E, Möller JC, Rieder P, Ruetti M, Stocker R, Vuichard-Gysin D, Wiggli B, Besold U, Kuster SP, McGeer A, Risch L, Friedl A, Schlegel M, Vernazza P, Kahlert CR. Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19-a prospective multicenter cohort study. BMC Med. 2021 Oct 14;19(1):270. 

DOI: 10.1186/s12916-021-02144-9

Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among hospital workers - A multicentre cross-sectional study.

Kahlert CR, Persi R, Güsewell S, Egger T, Leal-Neto OB, Sumer J, Flury D, Brucher A, Lemmenmeier E, Möller JC, Rieder P, Stocker R, Vuichard-Gysin D, Wiggli B, Albrich WC, Babouee Flury B, Besold U, Fehr J, Kuster SP, McGeer A, Risch L, Schlegel M, Friedl A, Vernazza P, Kohler P. Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among hospital workers - A multicentre cross-sectional study. Clin Microbiol Infect. 2021 Sep;27(9):1336-1344.

DOI: 10.1016/j.cmi.2021.05.014

A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease.

Schuppan D, Mäki M, Lundin KEA, Isola J, Friesing-Sosnik T, Taavela J, Popp A, Koskenpato J, Langhorst J, Hovde Ø, Lähdeaho ML, Fusco S, Schumann M, Török HP, Kupcinskas J, Zopf Y, Lohse AW, Scheinin M, Kull K, Biedermann L, Byrnes V, Stallmach A, Jahnsen J, Zeitz J, Mohrbacher R, Greinwald R; CEC-3 Trial Group. A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease. N Engl J Med. 2021 Jul 1;385(1):35-45.

DOI: 10.1056/NEJMoa2032441

 

Potentially inappropriate medications and medication combinations before, during and after hospitalizations: an analysis of pathways and determinants in the Swiss healthcare setting.

Migliazza K, Bähler C, Liedtke D, Signorell A, Boes S, Blozik E. Potentially inappropriate medications and medication combinations before, during and after hospitalizations: an analysis of pathways and determinants in the Swiss healthcare setting. BMC Health Serv Res. 2021 May 28;21(1):522. 

DOI: 10.1186/s12913-021-06550-w

Bronchodilator Response in Patients with COPD, Asthma-COPD-Overlap (ACO) and Asthma, Evaluated by Plethysmographic and Spirometric z-Score Target Parameters.

Kraemer R, Smith HJ, Gardin F, Barandun J, Minder S, Kern L, Brutsche MH. Bronchodilator Response in Patients with COPD, Asthma-COPD-Overlap (ACO) and Asthma, Evaluated by Plethysmographic and Spirometric z-Score Target Parameters. 2021a. International Journal of Chronic Obstructive Pulmonary Disease, 16, 2487-2500.

DOI: 10.2147/COPD.S319220

Normative reference equations of airway dynamics assessed by whole-body plethysmography during spontaneous breathing evaluated in infants, children, and adults.

Kraemer R, Smith HJ, Matthys H. Normative reference equations of airway dynamics assessed by whole-body plethysmography during spontaneous breathing evaluated in infants, children, and adults. 2021b. Physiological Reports, 9, e15027.

DOI: 10.14814/phy2.15027

Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19 - a prospective multicenter cohort study. BMC Medicine

Kohler P, Güsewell S, Seneghini M, […], Stocker R, […], et al. (2021).

DOI: s12916-021-02144-9

Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19 - a prospective multicenter cohort study. BMC Medicine

Kohler P, Güsewell S, Seneghini M, […], Stocker R, […], et al. (2021).

DOI: s12916-021-02144-9

Meeting Nutritional Targets of Critically Ill Patients by Combined Enteral and Parenteral Nutrition: Review and Rationale for the EFFORTcombo trial. Nutrition Research Reviews

Hill A, Heylang DK, Elke G, […] Stocker R, et al (2021).

DOI: 10.1017/S0954422420000165

2020

Wide area transepithelial sample esophageal biopsy combined with computer assisted 3-dimensional tissue analysis (wats3d) for detection of high grade dysplasia and adenocarcinoma in barrett: European multi-center, prospective, randomized, tandem study.

Raf Bisschops, Rehan Haidry, Helmut Messmann, Krish Ragunath, Pradeep Bhandari, Alessandro Repici, Miguel Muñoz Navas, Stefan Seewald, Arnaud Lemmers, Antoni Castells, Oliver Pech, Erik.J. Schoon, Revital Kariv, Horst Neuhaus, Bas L. Weusten, Peter D. Siersema,  loredana Correale, Frank B. Fromowitz, Gert De Hertogh, Jacques Bergman, Cesare Hassan. Wide area transepithelial sample esophageal biopsy combined with computer assisted 3-dimensional tissue analysis (wats3d) for detection of high grade dysplasia and adenocarcinoma in barrett: European multi-center, prospective, randomized, tandem study. Gastrointestinal Endoscopy, Volume 91, Issue 6, Supplement, 2020, Page AB23, ISSN 0016-5107,

DOI: https://doi.org/10.1016/j.gie.2020.03.063

2019

Arthroscopic and open treatment of cartilage lesions with BST-CARGEL scaffold and microfracture: A cohort study of consecutive patients.

Steinwachs M, Cavalcanti N, Mauuva Venkatesh Reddy S, Werner C, Tschopp D, Choudur HN. Arthroscopic and open treatment of cartilage lesions with BST-CARGEL scaffold and microfracture: A cohort study of consecutive patients. Knee. 2019 Jan;26(1):174-184.

DOI: 10.1016/j.knee.2018.11.015